MyJove CorporationJournal of Visualized Experiments1940-087X143201917Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS): Technique, Targeting, and Considerations10.3791/58984ENBashar W.BadranDepartment of Biomedical Engineering, City College of New York; U.S. Army Research Laboratory, Aberdeen Proving Ground; Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina; basharwbadran@gmail.comAlfred B.YuU.S. Army Research Laboratory, Aberdeen Proving GroundDevinAdairDepartment of Biomedical Engineering, City College of New YorkGeorgiaMappinBrain Stimulation Laboratory, Department of Psychiatry, Medical University of South CarolinaWilliam H.DeVriesBrain Stimulation Laboratory, Department of Psychiatry, Medical University of South CarolinaDorothea D.JenkinsDepartment of Pediatrics, Medical University of South CarolinaMark S.GeorgeBrain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina; Department of Neurology, Medical University of South Carolina; Ralph H. Johnson VA Medical CenterMaromBiksonDepartment of Biomedical Engineering, City College of New YorkJournal ArticleVideo-Audio Media10.3791/58984Non-invasive vagus nerve stimulation (VNS) may be administered via a novel, emerging neuromodulatory technique known as transcutaneous auricular vagus nerve stimulation (taVNS). Unlike cervically-implanted VNS, taVNS is an inexpensive and non-surgical method used to modulate the vagus system. taVNS is appealing as it allows for rapid translation of basic VNS research and serves as a safe, inexpensive, and portable neurostimulation system for the future treatment of central and peripheral disease. The background and rationale for taVNS is described, along with electrical and parametric considerations, proper ear targeting and attachment of stimulation electrodes, individual dosing via determination of perception threshold (PT), and safe administration of taVNS.